The two favourites were kept apart in the semi-final draw for the Fred Conway Cumberland Cup.
Carlisle United were handed a home tie against Whitehaven Miners Social.
And holders Workington Reds face an away semi against either Windscale or Maryport Athletic.
Monday night's draw raises the possibility of a first Reds-Blues final since 2007.
But both United and Workington will first have to get past west Cumbrian opponents who have impressed in their runs to the latter stages.
SEMI-FINAL | Earlier this evening, the #FredConwayCumberlandCup Semi-Final draw was made LIVE on @BBC_Cumbria
— Cumberland FA ⚽️ (@CumberlandFA) February 12, 2024
Holders Workington AFC await the winners of Windscale v Maryport Athletic while 3rd time semi-finalists Whitehaven Miners Social are away to Carlisle United!#CupRun 🏆 pic.twitter.com/qNTnQHhOCM
Whitehaven Miners Social, who are three-time semi-finalists, booked their last-four place with a 7-1 win at Alston Moor last weekend.
They sit sixth in the Cumberland County League Premier Division with games in hand on many sides above them.
The Coach Road outfit is also the former junior club of former Carlisle academy star Dean Henderson, who is now playing in the Premier League with Crystal Palace.
What a draw for the lads 👏 https://t.co/oYpIFwBCHf
— Whitehaven Miners FC (@W_Miners) February 12, 2024
United have reached the last four of the county senior cup thanks to victories over Carlisle City, Aspatria and Penrith in this season's competition. The Blues involved a number of first-team squad players in the City and Penrith ties.
Workington, meanwhile, will find out later this month who their last four opponents will be.
Windscale and Maryport Athletic meet next Wednesday in their quarter-final tie.
Danny Grainger's Reds, who lifted the trophy after defeating Penrith in last season's final at United's Brunton Park, saw off Unisun Athletic in this season's last eight.
The semi-finals are to be played on or before March 16. Last night's draw was made live on BBC Radio Cumbria.
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