Cumbrian Chris Harris will be out to get his hands on the Calcutta Cup after being named in the Scotland team for the Six Nations opener.
Gloucester Rugby star and British & Irish Lion Harris will take on England in the curtain-raiser at Murrayfield on Saturday.
The former Carlisle Rugby Club man will combine with Glasgow Warriors’ Sam Johnson in at centre after their selection was confirmed by head coach Gregor Townsend.
Harris, though, will not be joined on the field by another Cumbrian after England boss Eddie Jones did not select Jamie Blamire.
The Newcastle Falcons man, from Seaton, was named in the initial squad but is not included in the starting XV or the bench.
Exeter Chiefs’ Luke Cowan-Dickie has received the nod at hooker.
Scotland boss Townsend said: “We feel privileged to be involved in the oldest international rugby fixture on Saturday, against our nearest rivals.
“We are under no illusions on the tough challenge we have ahead of us against an England side who defeated the World Champions [South Africa] in their last outing.”
Jones said of England’s prospects: “As the first game, this match is hugely important to both sides and we will both want to get off to a winning start.
“We have a good, young team but we understand the task ahead and we’ll be ready to go after it from the first kick.”
Tom Curry, at 23, will be England’s youngest captain since Will Carling in 1988.
Kick-off on Saturday is 4.45pm and the game is live on BBC One.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here