Several of Carlisle United's relegation rivals are in action tonight.
A number of fellow strugglers will either be hoping to close or increase their gap to the Cumbrians near the foot of League Two.
Bottom side Scunthorpe United, who are six points behind the second-bottom Blues, are at home to third-placed Northampton Town.
Keith Hill's Scunny have lost ten of their last 11 league games and will tonight aim to cut the gap at the bottom to three points.
Colchester United could make Carlisle's survival job harder when they take on Hartlepool United at the Jobserve Community Stadium.
The fourth-bottom Us are three points above Keith Millen's side ahead of the game against the 12th-placed Monkey Hangers.
Wayne Brown's Essex outfit start a run of four successive home games tonight with United hoping Pools can keep Colchester within the Cumbrians' reach.
Leyton Orient will be looking to get back on track against Bristol Rovers at the Breyer Group Stadium.
Kenny Jackett's Os - United's hosts on Saturday - are currently 18th, five points above Carlisle, after nine league games without a win.
Rochdale, who came from behind to beat Scunthorpe 2-1 on Saturday, can further strengthen their survival attempt against Port Vale.
Robbie Stockdale's 17th-placed Dale are now six points above the drop zone as they hsost ninth-placed Vale.
Walsall, who beat leaders Forest Green Rovers in Mike Flynn's first game on charge on Saturday, go to Swindon Town. The Saddlers sit 16th, seven points above the Cumbrians.
Bradford City take on Harrogate Town at Valley Parade in tonight's other League Two game.
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