Paul Simpson's Carlisle United are 13/5 to continue their positive start to the season with a rare win at Colchester United.
The Blues have only ever won once at the JobServe Community Stadium.
That came back in 2017 when Jamie Devitt hit the winner.
Bookmakers give the Essex side the edge in their latest meeting on the second weekend of the season.
Wayne Brown's U's are 11/8 with SkyBet to take the points, and 11/10 with BetVictor.
A Carlisle victory in their first away game of 2022/23 is 13/5 with Betfair, 5/2 with Bet365 and 12/5 with William Hill.
The draw is 11/5.
Devitt, who should be back today after missing the opening game of the season with illness, is 14/1 to return and get the first goal this afternoon.
Kristian Dennis is 7/1 to repeat last weekend's opening-goal feat, and other United first scorer odds include Jordan Gibson at 12/1, Owen Moxon at 14/1 Jon Mellish at 16/1 and Omari Patrick - who got the opener in last season's meeting - at 9/1.
Freddie Sears is 5/1 to strike first for the home side with John Akinde 11/2 and Noah Chilvers 11/1. Both Sears and Chilvers were on target in their 3-2 defeat at Northampton on the opening day.
A repeat of last season's 2-2 draw between the two sides is available at 16/1, while another 1-0 win for the Blues is 9/1.
If you fancy Carlisle to hit the goal trail in a serious way, meanwhile, you can back them for four or more goals at 22/1.
A goal in the first ten minutes is 4/1, wihle United are 9/2 to score in both halves.
Source: Oddschecker
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here