Harry McKirdy is 11/2 to mark his return to Brunton Park with the first goal this afternoon.
Swindon Town's former Carlisle United striker opened the scoring on the Robins' last visit in February.
And he has the shortest odds of any player to find the net first today.
McKirdy, back from suspension today, is also 23/10 to score at any stage in the game - and 100/1 to claim a hat-trick against the Blues.
Paul Simpson's United, though, will be hoping to make it an unsuccessful return for the 25-year-old.
And key to the hosts' aim could be in-form frontman Kristian Dennis.
After scoring in Carlisle's first three games of the season, he is 5/2 to get another goal this afternoon.
READ MORE: The 60-year Carlisle United record in the sights of in-form Kristian Dennis
And Dennis is also 13/2 to strike first in the clash with Scott Lindsey's Swindon.
Other first-scorer odds for the Cumbrians include Jordan Gibson at 10/1, Owen Moxon at 14/1 and Jayden Harris at 18/1.
New signing Paul Huntington, who has said he does not expect to be involved today, is nonetheless priced at 33/1 for the first goal - shorter odds than more likely starters such as Jack Armer (40/1), Fin Back (50/1) and Corey Whelan (66/1).
Swindon, meanwhile, are marginal favourites for victory today.
Last season's losing play-off semi-finalists are 8/5 with Bet365.
Carlisle are 7/4 with the same bookmaker.
The draw is 23/10.
A repeat of Swindon's 3-0 win last season - a game that spelled the end for both manager Keith Millen and director of football David Holdsworth, and the return of Simpson - has odds of 30/1.
The same scoreline in United's favour is 35/1.
A second successive 1-0 home win for Simmo's side, meanwhile, is 8/1.
Swindon are yet to score after three games in league and cup, and are 29/10 to at least register today.
Source: Oddschecker.
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