Paul Simpson's Carlisle United are 12/5 to claim the scalp of his former club Derby County in the clubs' first league meeting since 1984.
Bet365 offer that price for a Cumbrians win at a packed Brunton Park this afternoon.
Other odds for a Blues victory against the Rams include 23/10 (SkyBet), 11/5 (William Hill) and 2/1 (BetUK).
Paul Warne's visitors have won two and lost one on the road so far in League One.
They are 23/20 with Betfair for the points in Cumbria and 11/10 with Bet365.
The draw is 13/5.
Two former Derby players will line up for Carlisle this afternoon.
Luke Plange is 9/1 to follow last weekend's opener at Lincoln City with the first goal against another of his former clubs today.
Midfielder Callum Guy, meanwhile, is 22/1 to open the scoring against the club where he started his career.
Other first scorer odds for Carlisle include Sean Maguire at 8/1, Joe Garner at 9/1, Jordan Gibson at 14/1, Owen Moxon at 14/1 and longer shots such as Fin Back (25/1), Paul Huntington (33/1) and Sam Lavelle (66/1).
For Warne's Pride Park outfit, five-goal Martyn Waghorn is 5/1 favourite to strike first, with Conor Washington and James Collins both 13/2.
Nathaniel Mendez-Laing is 12/1, Craig Forsyth 22/1 and new signing Ryan Nyambe 50/1.
Carlisle's last league meeting with Derby at Brunton Park, some 39 years ago, was a 2-1 win for the Blues in Division Two.
A repeat of that scoreline is 11/1.
Derby's last league win at Brunton Park came as far back as 1957 when the Rams won 3-1 in Division Three North.
A similar result in the visitors' favour is priced 16/1.
A second consecutive 1-1 draw for both clubs in League One this season, meanwhile, is 6/1.
Source: Oddschecker.
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