Carlisle United are 2/1 to record their first home win against Cambridge United for nearly 28 years.
Not since November 1996 have the Blues prevailed against the U's at Brunton Park.
Coral price a Cumbrians win at 2/1 with Bet365 offering 19/10 and 888Sport opting for 7/4.
Cambridge are unbeaten in ten visits to Carlisle's ground, and Neil Harris's side are 8/5 for the points with Unibet.
The 17th-placed side, marginal favourites with bookies this afternoon, are also 6/4 with William Hill and 31/20 with Sporting Index.
The draw is 12/5.
Luke Armstrong is 13/2 to get things going for Paul Simpson's Blues with the opening goal this afternoon.
Jack Diamond is 17/2 to open the scoring with his first goal for the club.
Other first scorer odds for the Cumbrians include Jordan Gibson at 12/1, Josh Vela at 20/1, Jon Mellish at 33/1 and Fin Back at 50/1.
For Cambridge, Lyle Taylor and Macaulay Bonne are both priced 15/2 for the opener.
George Thomas, who headed the winner when the sides met in October at the Abbey Stadium, is 12/1, with Paul Digby 25/1, Michael Morrison 30/1 and midweek scorer Danny Andrew 20/1.
Carlisle's last home win against the U's back in 1996 was a 3-0 victory under Mervyn Day.
A similar scoreline today in the Blues' favour is 33/1.
A more modest 1-0 win is 7/1 and a 2-1 home victory is 10/1.
Cambridge's last visit was a 2-1 win in March 2021 and they are 9/1 for the same today.
A 2-0 away win is 11/1 and a 0-0 draw is priced 8/1.
Source: Oddschecker.
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